Description

Scientist I/II, In Vivo Pharmacology

Location: Cambridge, MA

Requisition Number: 485

How will your role help us transform hope into reality?

 The Laboratory Animal Resources group at Blueprint Medicines is seeking a highly motivated, scientifically creative, and collaborative Scientist I/II, In Vivo Pharmacology, to work in a fast-paced environment within a cross-functional team. Laboratory Animal Resources (LAR) at Blueprint Medicines is an organization responsible for providing in vivo resources to enable drug discovery objectives relevant to pharmacology, DMPK, biopharmaceutics, tolerability, and translational medicine. LAR comprises an internal rodent vivarium, hands-on in vivo scientific staff, husbandry technicians, and an external attending veterinarian. The group is expanding its role to include responsibility for ex vivo cell and tissue work as well as management and oversight of external in vivo pharmacology studies at CROs. As Scientist I/II, you will be a key team member within the In Vivo Pharmacology group and the broader Quantitative Pharmacology and Drug Safety organization. Your responsibilities will include hands-on in vivo pharmacology model development, study execution, ex vivo work, and data interpretation to support Blueprint’s pipeline across various disease areas. In this fast-paced high impact role, you will have the opportunity to contribute scientifically to programs at various discovery and development stages.

 What will you do?

• Design, execute, and interpret in vivo pharmacology studies in rodents to evaluate the activities of small molecule drug candidates, investigate their mechanisms of action, and explore novel therapeutic hypotheses
• Work seamlessly with project teams and LAR to design and plan in-house pharmacology activities
• Perform ex vivo cell and tissue work, including but not limited to flow cytometry, ELISA, western blot, and quantitative RT-PCR
• Regularly analyze, document, and report in vivo and ex vivo data
• Regularly participate in project team meetings and present in vivo pharmacology research
• Manage in vivo pharmacology studies being performed at CROs
• Perform other responsibilities as assigned

 What minimum qualifications do we require?

• PhD in the biological sciences plus 1+ years of relevant postdoctoral or biopharmaceutical experience/ MS degree plus 5+ years relevant biopharmaceutical experience

What additional qualifications will make you a stronger candidate?

• Hands-on experience designing and performing in vivo disease models in rodents, including tumor models or inflammatory disease models to assess efficacy and PK/PD is essential
• Hands-on experience with various routes of administration in rodents is essential
• Hands-on experience with rodent tissue collection and ex vivo processing techniques
• Strong oral and written communication skills, as well as excellent documentation and organizational skills are essential
• Strong interpersonal and communication skills, with a passion for participating in a fast-paced environment characterized by challenging and rigorous science, and creative thinking
• Experience with standard software analytical tools including Excel and GraphPad Prism
• Collaborative with effective listening skills and open, clear, consistent communication abilities

• Hands-on experience with murine tumor models and/or tumor xenograft models
• Experience working with small molecule therapies and characterizing PK/PD relationships
• Experience in management and oversight of external in vivo pharmacology studies at CROs
• Hands-on experience with multiparameter flow cytometry
• Ability to work effectively with project leads and project teams that have diverse personalities and styles
• Ability to work effectively with all collaborators in the drug discovery process: chemistry, DMPK, toxicology, bioinformatics, biology, clinical pharmacology, and translational medicine
• Commitment to Blueprint Medicines’ Core Values: Patients First, Thoughtfulness, Urgency, Trust, Optimism

Why Blueprint? 

At Blueprint Medicines, we achieve impactful results because of our global crew of compassionate innovators – the Blue Crew. Through authentic relationships and our collective entrepreneurial spirit and action, we are each empowered to take ownership and execute with strategic prioritization. We put trust in our people to break through norms and conventions using their individual strengths and insights, which drives our success.

This is the place where the extraordinary becomes reality, and you could be part of it. Patients are waiting. Are you ready to make the leap? 

COVID-19 Vaccination Requirement

As a biotechnology organization, it is our responsibility to do everything we can to safeguard the health and safety of our workforce, our communities, and the patients we serve.  That is why, prior to their start date, new hires must provide confirmation that they are fully vaccinated against COVID-19, or be approved by Blueprint for an exemption for health reasons contraindicating the vaccines or sincerely held religious beliefs.  Accommodation requests for either of these reasons should be made to TotalRewards@blueprintmedicines.com.

Equity, Diversity, Inclusion and Affirmative Action

At Blueprint Medicines, we foster a culture of equity, diversity and inclusion.  A proud Equal Employment Opportunity and Affirmative Action employer, we consider all qualified applicants without regard to race, color, sex, gender identity or expression, sexual orientation, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, or any other characteristic protected under applicable law.  We are also an E-Verify Employer.  We will make reasonable accommodations, absent undue hardship, for qualified individuals with known disabilities. If you are an individual with a disability in need of an accommodation with the application or recruiting process, please reach out to TotalRewards@blueprintmedicines.com. 

For more information, please see our EEO-AA Policy Statement, the EEO Poster and its Supplement, as well as our Pay Transparency Statement. 

Blueprint Medicines is a global precision therapy company that invents life-changing therapies for people with cancer and blood disorders. Applying an approach that is both precise and agile, we create medicines that selectively target genetic drivers, with the goal of staying one step ahead across stages of disease. Since 2011, we have leveraged our research platform, including expertise in molecular targeting and world-class drug design capabilities, torapidly and reproducibly translate science into a broad pipeline of precision therapies. Today, we are delivering approved medicines directly to patients in the United States and Europe, and we are globally advancing multiple programs for systemic mastocytosis, lung cancer and other genomically defined cancers, and cancer immunotherapy. For more information, visit www.BlueprintMedicines.com and follow us on Twitter (@BlueprintMeds) and LinkedIn.