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11 hours ago
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1 - 13 Results of 13
Blueprint Medicines
Cambridge, Massachusetts, United States
11 hours ago


Senior Scientist I/II, Clinical Pharmacology

Location Cambridge, MA

Requisition Number: QPDS21-901

Blueprint Medicines is a global precision therapy company that invents life-changing therapies for people with cancer and hematologic disorders. Applying an approach that is both precise and agile, we create medicines that selectively target genetic drivers, with the goal of staying one step ahead across stages of disease. Since 2011, we have leveraged our research platform, including expertise in molecular targeting and world-class drug design capabilities, to rapidly and reproducibly translate science into a broad pipeline of precision therapies. Today, we are delivering approved medicines directly to patients in the United States and Europe, and we are globally advancing multiple programs for genomically defined cancers, systemic mastocytosis, and cancer immunotherapy.

What will you do?

Blueprint Medicines is seeking an experienced clinical pharmacologist with expertise in pharmacometrics and who is motivated by the opportunity to have an outsized impact across drug discovery and development. As a Senior Scientist of Clinical Pharmacology and a member of the larger Quantitative Pharmacology and Drug Safety (QPDS) team, you will use your experience to lead quantitative pharmacology efforts and provide clinical pharmacology and pharmacometrics support. We look forward to you accelerating our growing portfolio of preclinical and clinical development candidates in a variety of precision oncology and rare disease indications.

What will be your responsibilities?

  • Provide quantitative clinical pharmacology (i.e., physiologically based pharmacokinetic (PBPK) modeling and model informed drug development (MIDD)) support to cross functional clinical project teams
  • Assist/lead in the analysis, interpretation and reporting of clinical pharmacology data
  • Assist/lead in the development of PK/PD modeling (i.e., population PK modeling, PK-PD modeling, Exposure-Response modeling, and modeling).
  • Assist/lead developing clinical pharmacology plans (e.g., assessment of QT, food effect, ADME, DDI strategy, special populations, etc.) to support development and rapid registration
  • Plan, design, execute and report program-specific clinical pharmacology studies by working cross-functionally with Clinical Operations and Clinical Research
  • Work collaboratively with CRO’s/external vendors to ensure compliance with planned study protocols, internal quality standards and timelines
  • He/she will assist in preparation of regulatory documents (CTD, Investigator brochure (IB), EOP2 meetings, NDA/MAA) for submission to global health authorities

What qualifications do we require?

  • PhD or Pharm D in Clinical Pharmacology, Pharmacokinetics, or a related subject area with at least 3 years of proven ability in pharmacometrics and clinical pharmacology
  • PBPK modeling experience

What qualifications do we prefer?

  • Passion for effective communication and cross-functional collaboration
  • Ability to thrive in a fast-paced, dynamic environment and under competitive timelines
  • Outstanding project management and people skills

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.

Who we are:

We don’t think in small steps. We think in giant leaps.

We are driven by the pursuit of new ideas, new innovations, and new ways of thinking.

We know that what each and every one of us matters and that our success depends on our ability to work together in a diverse community.  We believe we are at our best as a company when our employees are thriving and foster a culture that provides opportunities to grow and develop professionally, while also having fun.

Job Information

  • Job ID: 57916616
  • Location:
    Cambridge, Massachusetts, United States
  • Position Title: Senior Scientist I/II, Clinical Pharmacology
  • Company Name: Blueprint Medicines
  • Job Function: Pharmacology
  • Job Type: Full-Time
  • Job Duration: Indefinite
  • Min Education: Ph.D.
  • Min Experience: 3-5 Years

Please refer to the company's website or job descriptions to learn more about them.

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